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SANE Vitaae™ Reviews: Does this Postbiotic Supplement Work?

SANE Vitaae™users are raving about this groundbreaking brain-boosting supplement. They've even taken the time to write glowing Vitaee™ reviews. 

Here's a Typical Vitaae™ Review


"Vitaae™ has literally changed my life and the lives of my family. I can enjoy them now that I'm no longer an invalid! I feel like those "rare moments" of clarity I used to have are just the way my mind works now. 

My daughter also takes Vitaae™ and I can vouch for the improvement in her energy and disposition. We've heard that Vitaae™ can help with attention, so we're working to make Vitaae™ a habit with my grandsons. 

I have the energy & ability to be active in volunteer endeavors and just 'feel good' and 'Happy'! I'm not sure what else I can say except "THANK YOU FOR CARING''.

-Jean S


An image of a bottle of SANE Vitaae with 5 gold stars.

How Does Vitaae™ Work?

With Vitaae™, you can leave behind brain fog and improve your mental clarity, while keeping your memories safe. 

Vitaae™ provides highly-researched nutrients to reduce or eliminate brain inflammation so that your brain can perform at its best. This, in turn, will help improve all areas of your mental and physical health. It may even have an anti-aging effect!

Why is Brain Inflammation so Dangerous?

A 3-d rendering of a man with a reddened, inflamed brain having a headache.

Brain inflammation is often the hidden cause of “brain problems” as we age.  And it's more common than most people think.

The type of brain inflammation that usually makes the news is caused by viral or bacterial meningitis, a dangerous and even deadly condition. Fortunately, meningitis is rare. A much more common cause of neuroinflammation is toxins and other dangerous substances entering the brain. These substances activate microglia cells, triggering inflammation. 

And unlike dangerous viral and bacterial brain infections, this type of inflammation is chronic. You can carry it in your brain for years, even decades. Oh, you’ll have symptoms, but you’ll probably write them off as just a normal part of aging. 

Do any of these symptoms sound familiar?

  • Memory Loss
  • Weight gain
  • Mood swings
  • Mental disorders, such as anxiety and depression
  • General cognitive decline
  • Brain fog
  • Lack of energy

If so, you may have neurological inflammation. 

This is just a partial list, though. Since your brain controls every bodily function, the symptoms of brain inflammation can affect many aspects of your health. It has even been linked to diabetes!

Leaky Brain and Neurological Inflammation

Did you know that there is a hidden epidemic that causes most of the symptoms we consider "just a part of aging?" It's true.

Doctors are calling this hidden epidemic one of the most overlooked public health crises of our generation and you need to know about it.  It has become so common they even have a nickname for it… Leaky Brain Syndrome or LBS. 

You see, inflammation is the body’s natural response to protect itself from toxins, pathogens, viruses or any other type of trauma or injury. However, inflammation is not necessary (or desirable) in your brain because it is protected by the blood brain barrier.

But if the barrier is compromised, it becomes "leaky" allowing toxins, pathogens, and bacteria to enter. This activates what are called microglia cells that cause brain inflammation. Doctors call this "leaky brain syndrome."

This inflammatory response can then shut down energy production in brain cells, causing your brain to literally slow down as your neurons are firing slower. As you can imagine, shutting down energy production in brain cells and slowing down the firing of neurons severely breaks down every system in the body. 

 Again, we often call these consequences “aging” but they are 100% optional as you will soon see! Certainly, our customers have experienced some phenomenal anti-aging benefits. Here are a few more Vitaae reviews from verified users.

Vitaae™ Reviews


"It’s safe to say that I have never tried anything, prescription medications included, that have had such an immediate and noticeable impact on my life everyday. Thanks!"

-Gloria R


"You know how you go into a room and forget why? That doesn’t happen anymore. I had always been terrible with names, but it’s like they automatically stick in my mind now. I even remembered our wedding anniversary without any reminders this year (my wife couldn’t believe it)."

-Robert W 


"I just love this! I have been taking it for 2 months now, and my brain fog is nearly gone. I have more energy. I exercise more, and I feel very vibrant all over, not just mentally. And I am down 7 pounds so that is a bonus."

-Terry L 


"Vitaae™ is everything it is advertised to be. I have a calm demeanor all through my day. I also do not have cravings that I have fought for years. That has helped me to eat healthier. Love it!"

 -Kathy N


Health Benefits of SANE Vitaae™

Aids Weight Loss

An image of a slim woman in jeans pulling holding out the waistband to show her weight loss.

Like everything else, the brain controls your metabolism and your ability to lose weight. Specifically, this is managed by the hypothalamus in your brain.

The hypothalamus is in charge of balancing calories in and calories out so that ideally the body never becomes too fat or too thin. It depends on hormones to tell it whether you're full and how much body fat you have. 

But if the hypothalamus becomes inflamed, it receives incorrect information from your brain and hormones. How does this work?

The hypothalamus is regulated in large part by the hormones leptin and insulin. When the brain is healthy, these hormonal signals are received correctly so that when calorie intake increases your body simply burns more calories.  In other words your weight balances at your setpoint weight. 

So, if you have a healthy non-elevated setpoint, you automatically maintain a healthy weight. (You're one of those "naturally thin" people...until certain factors inflame your brain and elevates your  setpoint weight.)

That's right...neurological inflammation causes these signals to stop working properly and instead of trying to keep you naturally slim, your hypothalamus and hormones instead work to hold on to extra fat, no matter how hard you try to lose the weight. 

This connection between brain inflammation and weight gain is breakthrough research that is changing the weight loss world forever. For example, a 2016 study in The Journal of Nutritional Biochemistry states: 

"Current evidence shows hypothalamic inflammation as a likely mechanism for the dysregulation on the homeostatic control of energy balance, which leads to metabolic alterations and obesity."1

If this is the underlying cause of weight gain, eliminating brain inflammation should result in effortless weight loss!

Eases Multiple Components of Metabolic Syndrome

Metabolic syndrome is a cluster of conditions that occur together, increasing your risk of type 2 diabetes, stroke, and heart disease. These conditions include excess fat around the stomach, increased blood pressure, increased belly fat, high blood sugar, and abnormal cholesterol levels.

And guess what?

Research is showing that hypothalamic inflammation may be causing multiple components of metabolic syndrome, also known as “syndrome X” leading to severe obesity, diabetes and cardiovascular disease. Truly, every aspect of your body is deeply impacted by this! (2)

May Defend Against Alzheimer's Disease 

An illustration of three human brains showing the progression of Alzheimer's disease with text that reads Progression of Alzheimer's Disease, healthy brain, mild Alzheimer's disease, severe Alzheimer's disease.

Alzheimer's is a brain disease in which cognitive impairment gradually worsens, leading to total disability and death. This condition has become increasingly and distressingly common, mostly among the elderly.

According to the Alzheimer's Association, 1 in ten people age 65 and over have this disease. (That's 10% of the elderly population.)3

And there is scientific evidence that neurological inflammation may be the underlying cause of Alzheimer's and other forms of dementia. 

For instance, according to a study by the University of Cambridge: 

"Inflammation of the central nervous system is increasingly regarded as having a role in cognitive disorders such as dementia."4

And even more studies are being conducted right now that are examining the connection between neuroinflammation and Alzheimer's Disease. 

In fact, a recent 2015 study published in the Journal of Neuroscience begins with this sentence:

"Neuroinflammation has long been known as an accompanying pathology of Alzheimer’s disease."5

This cutting-edge research into neurological inflammation could one day lead to a cure for one of our most disabling and deadly diseases!

Supports Proper Brain Function and Memory

And of course, brain inflammation negatively affects proper brain function and memory. 

As another study published in the Journal of Neuroscience stated:

"Stress-induced neuroinflammation impairs hippocampal neurogenesis and promotes cognitive and affective behavioral deficits."6, 7

So if you suffer from brain fog, low energy, trouble focusing or other memory related problems, it’s not because you are getting older, it may be because you are suffering from severe neurological inflammation. 

Improves Mood

An image of a man showing sad and happy smileys on wooden cube.

Mood disorders are also becoming increasingly common. 

For instance, anxiety disorders are the most common mental issue in the United States. Anxiety affects an estimated 40 million adults every year. (That's 18.1% of the population.)8

And brain inflammation could be a main cause of these mood disorders.

A 2017 Cambridge University study found that:

“Inflammation in the brain is increasingly being recognized as playing in a role in depression, and other mood disorders.”9

Another 2017 study published in Neurology Journal showed that participants that showed higher inflammatory brain activity had higher levels of depression and anxiety.10

Natural Ingredients in Vitaae™

Here are the main clinically proven brain-healing ingredients in SANE Vitaae™.


You’ve probably heard that folate (vitamin B-9) is a pregnancy or prenatal vitamin. It is true that folate helps ensure normal fetal development, particularly of the unborn baby’s brain and spinal cord. But folate is an important nutrient for all people of all ages.

Neurologists at King’s College found that folic acid (a synthetic form of folate) affects cognitive function, especially in older people. And folate deficiency may increase the risk of Alzheimer’s disease and dementia in the older population.11

It is clear that folate is one of the best vitamins for brain health, especially as we age. But this nutrient, too, is one that many people are deficient in. That’s because many of us can no longer produce the enzyme MTHFR required for us to absorb the folate from foods or from most supplements. And even if we can produce this enzyme, folate is easily destroyed during cooking and food processing. 

The solution?

Vitaae™ contains MagnaFolate™, a patented form of folate that has been shown to be up to 7 times more absorbable than conventional folate supplements found on store shelves.12 


Citicoline is a natural occurring chemical present in every cell of the body. It is among the best vitamins for brain health because of its direct effect on neurotransmitter function. In fact, the US Institute of Medicine found that citicoline can “alleviate or improve memory impairment.”13

A study from the University of Oslo also found a direct link between low levels of choline (the precursor of citicoline) and poor cognitive performance.14

You can get citicoline through your diet, but you’d need to eat a dozen eggs per day to get enough choline. This is why a large portion of the population is deficient in this important brain-boosting  nutrient.   

Vitaae™ contains patented Cognizin™ citicoline that’s proven to  support brain cellular synthesis, brain energy, and focus. In clinical trials, Cognizin™ significantly decreased focus errors in middle aged women.15 It also showed a 13.6% increase in brain energy utilization16 and a 26% increase in membrane turnover,17 having an anti-aging effect on your brain!  


Acetyl-L-carnitine, a form of L-carnitine, is an amino acid your body produces naturally. L-carnitine plays a crucial role in energy production. It moves fatty acids into your cells so it can be used for energy. Studies have shown that an increase of L-carnitine in a diet significantly increases the breakdown of fat.18

Acetyl-L-carnitine takes this energy-producing power to the brain, where it easily crosses the blood-brain barrier, improving blood flow to the brain. It has been shown to improve memory, mood, and learning abilities. 

And it really is an anti-aging super nutrient even for people who are over 80 years old! Specifically, a study from 2007, showed that participants over 80 years old who supplemented with L-carnitine had significant improvements in energy, muscle mass and mental function—plus, less fatigue and fat mass.19

Though you can get carnitine through your diet -- red meats and dairy products are rich sources of carnitine -- most adults are chronically low in this nutrient and many need a daily supplement. A daily dose of Vitaae™ provides the perfect amount of L-carnitine your brain and body needs!

Coenzyme Q-10

Coenzyme Q10, known as CoQ10, is an antioxidant naturally produced by your body. It lives within the mitochondria of every cell. The mitochondria are the energy-producing part of the cells, and CoQ10 sparks energy within these cells. It especially ignites energy within heart and brain cells. 

This means CoQ10 can support heart and brain health. Studies show that this nutrient not only helps fix brain-related issues, but it may also help reduce risk of cardiovascular disease.

Though the body makes CoQ10, levels of this nutrient decrease with age, leaving millions of people deficient in this important nutrient. Taking a CoQ10 supplement is key to avoiding a deficiency...but not all supplements are absorbable and bioavailable. 

The new patented MicroActive™ CoQ10 in Vitaae™ is the only form available that offers 100% “assured bioavailability” to everyone. 

Vitaae™: The Last and Only Brain Health Supplement You'll Ever Need

An image of a bottle of SANE Vitaae.

Are you ready to say goodbye to the “leaky brain” and neurological inflammation that is often the cause of so many of the symptoms of aging?

Get ready to reclaim your youthful energy and mental clarity from the inside out with new, patented, and clinically proven ingredients that have never been put together into a single, easy-to-take formula before.

Customer Reviews


"I was a nurse for 30 years. So I put a lot of attention to what I put into my body, and I am always hesitant about supplements. But I have to say after doing my own in-depth research on the formulation, the ingredients, especially the well studied patented versions, are really top notch."

-Helen K


"At 62, Vitaae™ is the one thing that has really helped me to have a better attitude, a better outlook and a sharper mind. I feel like I have more energy and have lost 5 pounds already, as I am definitely more active. I have been so disappointed with the mental focus products out there because none have worked until trying Vitaae."

-Camilla A


"My mom has Alzheimer’s and did really well on Vitaae™, getting a lot of her speech back. She decided to try 6 months without it and her speech declined quickly. She is taking it again now, and hoping her speech returns to the previous level."

 -Jill S


"I felt better on the very first day. I'm now ordering my 3rd+ bottles. Less fog, and short-term memory loss. Overall healthier. Losing weight, too!"

-Joanne W



1- Cesar HC, Pellegrini Pisani L. Fatty-acid-mediated hypothalamic inflammation and epigenetic programming. The Journal of Nutritional Biochemistry. Volume 42. 2017. Pages 1-6. ISSN 0955-2863.


2- Cai D, Liu T. Hypothalamic inflammation: a double-edged sword to nutritional diseases. Ann N Y Acad Sci. 2011;1243:E1-E39. doi:10.1111/j.1749-6632.2011.06388.x


3- Alzheimer’s Association. Alzheimer’s Fact and Figures. Accessed Jul 26, 2021.,65%20and%20older%20%2810%20percent%29%20has%20Alzheimer%27s%20dementia.


4- Bevan-Jones WR, Surendranathan A, Passamonti L, et al. Neuroimaging of Inflammation in Memory and Related Other Disorders (NIMROD) study protocol: a deep phenotyping cohort study of the role of brain inflammation in dementia, depression and other neurological illnesses. BMJ Open. 2017;7(1):e013187. Published 2017 Jan 7. doi:10.1136/bmjopen-2016-013187


5- Ardura-Fabregat A, Boddeke EWGM, Boza-Serrano A, Brioschi S, Castro-Gomez S, Ceyzériat K, Dansokho C, Dierkes T, Gelders G, Heneka MT, Hoeijmakers L, Hoffmann A, Iaccarino L, Jahnert S, Kuhbandner K, Landreth G, Lonnemann N, Löschmann PA, McManus RM, Paulus A, Reemst K, Sanchez-Caro JM, Tiberi A, Van der Perren A, Vautheny A, Venegas C, Webers A, Weydt P, Wijasa TS, Xiang X, Yang Y. Targeting Neuroinflammation to Treat Alzheimer's Disease. CNS Drugs. 2017 Dec;31(12):1057-1082. doi: 10.1007/s40263-017-0483-3. PMID: 29260466; PMCID: PMC5747579.


6- Ardura-Fabregat A, Boddeke EWGM, Boza-Serrano A, Brioschi S, Castro-Gomez S, Ceyzériat K, Dansokho C, Dierkes T, Gelders G, Heneka MT, Hoeijmakers L, Hoffmann A, Iaccarino L, Jahnert S, Kuhbandner K, Landreth G, Lonnemann N, Löschmann PA, McManus RM, Paulus A, Reemst K, Sanchez-Caro JM, Tiberi A, Van der Perren A, Vautheny A, Venegas C, Webers A, Weydt P, Wijasa TS, Xiang X, Yang Y. Targeting Neuroinflammation to Treat Alzheimer's Disease. CNS Drugs. 2017 Dec;31(12):1057-1082. doi: 10.1007/s40263-017-0483-3. PMID: 29260466; PMCID: PMC5747579.


7- McKim DB, Niraula A, Tarr AJ, Wohleb ES, Sheridan JF, Godbout JP. Neuroinflammatory Dynamics Underlie Memory Impairments after Repeated Social Defeat. Journal of Neuroscience 2 March 2016, 36 (9) 2590-2604; DOI:


8- Anxiety and Depression Association of America. Facts and Statistics. Accessed Jul 26, 2021.,of%20disability%20worldwide.%20...%204%20Treatment%20Options.%20


9- Bevan-Jones WR, Surendranathan A, Passamonti L, et al. Neuroimaging of Inflammation in Memory and Related Other Disorders (NIMROD) study protocol: a deep phenotyping cohort study of the role of brain inflammation in dementia, depression and other neurological illnesses. BMJ Open. 2017;7(1):e013187. Published 2017 Jan 7. doi:10.1136/bmjopen-2016-013187


10- Rossi S, Studer V, Motta C, Polidoro S, Perugini J, Macchiarulo G, Giovannetti AM, Pareja-Gutierrez L, Calò A, Colonna I, Furlan R, Martino G, Centonze D. Neuroinflammation drives anxiety and depression in relapsing-remitting multiple sclerosis. Neurology Sep 2017, 89 (13) 1338-1347; DOI: 10.1212/WNL.0000000000004411


11- Reynolds EH. Folic acid, ageing, depression, and dementia. BMJ. 2002;324(7352):1512-1515. doi:10.1136/bmj.324.7352.1512


12- Willems FF, et al. Br J Pharmacol. 2004 Mar;141(5):825-30. [PMID: 14769778]


13- Poly C, Massaro JM, Seshadri S, et al. The relation of dietary choline to cognitive performance and white-matter hyperintensity in the Framingham Offspring Cohort. Am J Clin Nutr. 2011;94(6):1584-1591. doi:10.3945/ajcn.110.008938


14- Nurk E, Refsum H, Bjelland I, Drevon CA, Tell GS, Ueland PM, Vollset SE, Engedal K, Nygaard HA, Smith DA. Plasma free choline, betaine and cognitive performance: the Hordaland Health Study. Br J Nutr. 2013 Feb 14;109(3):511-9. doi: 10.1017/S0007114512001249. Epub 2012 May 1. PMID: 22717142.


15- Silveri MM et al. Citicoline enhances frontal lobe bioenergetics as measured by phosphorus magnetic resonance spectroscopy. NMR Biomed. 2008;21(10):1066-75


16- McGlade E. et al., Improved Attentional Performance Following Citicoline Administration in Healthy Adult Women. Food and Nutrition Sciences. 2012;3:769-773.


17- Yurelun-Todd D et al. The Effects of Citicoline Supplementation on Motor Speed and Attention in Adolescent Males. J0urnal of Attention Disorders. 2015; 1557-1246


18- Wutzke KD, Lorenz H. The effect of l-carnitine on fat oxidation, protein turnover, and body composition in slightly overweight subjects. Metabolism. 2004 Aug;53(8):1002-6. doi: 10.1016/j.metabol.2004.03.007. PMID: 15281008.


19- Malaguarnera M, Cammalleri L, Gargante MP, Vacante M, Colonna V, Motta M. L-Carnitine treatment reduces severity of physical and mental fatigue and increases cognitive functions in centenarians: a randomized and controlled clinical trial. Am J Clin Nutr. 2007 Dec;86(6):1738-44. doi: 10.1093/ajcn/86.5.1738. PMID: 18065594.

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