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Tributyrin and Butyrate

Have you heard the news about Tributyrin yet? If not, you’ll be hearing a lot about it soon, especially if you suffer from gastrointestinal issues.

Tributyrin is clinically proven to help fix so many of the painful and sometimes embarrassing gut-health problems -- such as gas, bloating, constipation, even leaky gut -- that plague millions of people worldwide.  

What is Tributyrin and Butyrate?

Tributyrin is a triglyceride that is naturally found in trace amounts in butter, and it is also available in supplement form.

When consumed, Tributyrin is converted into butyrate.

Research shows that Tributyrin is the superior form of butyrate for digestion, absorbability, and bioactivity. It has also been proven to be more potent in inhibiting the growth of human colon cancer cells.1

Butyrate is the key factor here.

Butyrate is one of three main short chain fatty acids produced by bacterial fermentation in your colon. (The other two are acetate and propionate.)

Collectively, they represent 90% to 95% of the short-chain fatty acids in the colon.2

Butyrate is the least abundant short chain fatty acid produced in the colon.3

Take a look at the estimated percentages of each short-chain fatty acid produce by bacterial fermentation:

Acetate: 60%
Propionate: 25%
Butyrate: 15%4

Incredibly, this small amount of butyrate is responsible for 60% to 70% of the energy requirements of epithelial cells of the colon.5

What are the Gut Health Benefits of Butyrate?

Though more research is needed to determine all the health benefits of butyrate, it is clear that butyrate plays a key role in maintaining intestinal balance.6

Multiple research studies indicate that butyrate may reduce gut inflammation, protect the intestinal barrier, maintain the balance of good and bad intestinal bacteria, facilitate absorption of electrolytes by the large intestine, and so much more.7,8,9,10

This means that butyrate may help fix many of the most common gastrointestinal issues and disorders, including:

  • Gas
  • Bloating
  • Abdominal cramps
  • Diarrhea
  • Constipation
  • Irritable bowel syndrome (IBS)
  • Crohn’s Disease
  • Celiac disease
  • And more.

Why Can’t I Take Butyrate Supplements?

There are two reasons why you can’t (shouldn’t) take butyrate supplements.

  1. Butyrate is a “stinky” nutrient that would discourage most people from taking it.
  2. Butyrate is what is considered an “unstable” molecule, meaning that it dissolves long l before getting to your lower colon.

Can butyrate be made more “stable”?

YES!

After years of research, scientists have combined 3 Butyrate molecules with a glycerol molecule to create a radically more effective version of this “optimal” short chain fatty acid.

The result is Tributryn, a supplement shown to be more potent than other forms of butyrate for colon health.11

Introducing Viscera-3 for Gut Health!

Our POSTbiotic formula Viscera-3 contains the superior branded form of Tributryn -- TRIButyrate®!

This superior form of TRIbutyrate® is time-released directly into your lower colon (the only place it can provide all these life-changing benefits). That is why it is the main active ingredient in our new one-of-a-kind gut health breakthrough Viscera-3TM.

TRIbutyrate is three times more potent than the weak short chain fatty acids created by fiber alone.

Then we combined TRIbutyrate with our SLIMGut Earth Minerals Matrix™ and the SLIMGut Garden Blend™. Together their powerful multi-factor effect on gut health leads to less gas, constipation, bloating, and of course faster weight loss!

Click here to learn more about SANE Viscera-3 and to see if we still have this wildly popular "gut healing" formula in stock. 

References

1- Gaschott T, Steinhilber D, Milovic V, Stein J. Tributyrin, a Stable and Rapidly Absorbed Prodrug of Butyric Acid, Enhances Antiproliferative Effects of Dihydroxycholecalciferol in Human Colon Cancer Cells, The Journal of Nutrition, Volume 131, Issue 6, June 2001, Pages 1839–1843

2- Ríos-Covián D, Ruas-Madiedo P, Margolles A, Gueimonde M, de Los Reyes-Gavilán CG, Salazar N. Intestinal Short Chain Fatty Acids and their Link with Diet and Human Health. Front Microbiol. 2016;7:185. Published 2016 Feb 17. doi:10.3389/fmicb.2016.00185

3- Liu H, Wang J, He T, Becker S, Zhang G, Li D, Ma X. Butyrate: A Double-Edged Sword for Health?, Advances in Nutrition, Volume 9, Issue 1, January 2018, Pages 21–29

4- Liu H, Wang J, He T, Becker S, Zhang G, Li D, Ma X. Butyrate: A Double-Edged Sword for Health?, Advances in Nutrition, Volume 9, Issue 1, January 2018, Pages 21–29

5- Liu H, Wang J, He T, Becker S, Zhang G, Li D, Ma X. Butyrate: A Double-Edged Sword for Health?, Advances in Nutrition, Volume 9, Issue 1, January 2018, Pages 21–29

6- Leonel AJ, Alvarez-Leite JI. Butyrate: implications for intestinal function. Curr Opin Clin Nutr Metab Care. 2012 Sep;15(5):474-9. doi: 10.1097/MCO.0b013e32835665fa. PMID: 22797568.

7- Andoh A, Bamba T, Sasaki M. Physiological and anti-inflammatory roles of dietary fiber and butyrate in intestinal functions. JPEN J Parenter Enteral Nutr. 1999 Sep-Oct;23(5 Suppl):S70-3. doi: 10.1177/014860719902300518. PMID: 10483900.

8- Michielan A, D'Incà R. Intestinal Permeability in Inflammatory Bowel Disease: Pathogenesis, Clinical Evaluation, and Therapy of Leaky Gut. Mediators Inflamm. 2015;2015:628157. doi:10.1155/2015/628157

9- Velazquez, OC, Lederer HM, and Rombeau JL. Butyrate and the colonocyte. Production, absorption, metabolism, and therapeutic implications. Adv Exp Med Biol 427: 123-134, 1997.

10- den Besten G, van Eunen K, Groen AK, Venema K, Reijngoud DJ, Bakker BM. The role of short-chain fatty acids in the interplay between diet, gut microbiota, and host energy metabolism. J Lipid Res. 2013;54(9):2325-2340. doi:10.1194/jlr.R036012

11- Gaschott T, Steinhilber D, Milovic V, Stein J. Tributyrin, a Stable and Rapidly Absorbed Prodrug of Butyric Acid, Enhances Antiproliferative Effects of Dihydroxycholecalciferol in Human Colon Cancer Cells, The Journal of Nutrition, Volume 131, Issue 6, June 2001, Pages 1839–1843, https://doi.org/10.1093/jn/131.6.1839

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